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CAS No. 13010-47-4 | Lomustine

Name: Lomustine CAS No. 13010-47-4 MF:C9H16ClN3O2 MW:233.7 Purity:98% Package: 5g,25g,200g,500g,1kg Worldwide Delivery

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Product introduction

Introduction and application of CAS No. 13010-47-4 | Lomustine

Synonyms:(chloro-2-ethyl)-1-cyclohexyl-3-nitrosourea;

(cloro-2-etil)-1-cicloesil-3-nitrosourea;

1-(2-chloroethyl)-3-cyclohexyl-1-nitrosoure;

1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-ure;

Specification:

ITEMS	SPECIFICATION
CAS	13010-47-4
MF	C9H16ClN3O2
MW	233.7
Melting point	88-90
Boiling point	63.6°C
Density	1.3840
Acidity coefficient	10.88±0.20
Color	light orange to yellow to green
Solubility	Almost insoluble in water, easily soluble in acetone and methylene chloride, and soluble in ethanol (96%).
Storage condition	2-8°C

Clinical application:

Lomustine is an alkylating drug indicated for the treatment of patients with: primary and metastatic brain tumors following appropriate surgical and/or radiation therapy procedures. Second-line treatment for Hodgkin lymphoma, used in combination with other chemotherapy drugs, for patients who have relapsed or failed to respond to primary treatment.

Physical and chemical properties:

Appearance and properties of lomustine: This product is a light yellow crystalline powder; odorless. It is easily soluble in chloroform, soluble in ethanol or carbon tetrachloride, slightly soluble in cyclohexane, and almost insoluble in water. It is commonly used for primary brain tumors (such as glioblastoma) and secondary tumors; for the treatment of solid tumors, such as combined treatment of gastric cancer, rectal cancer, bronchial lung cancer, malignant lymphoma, etc.

Chemical properties:

Yellow powder. Melting point 90℃. The solubility in water, 0.1N sodium hydroxide solution, 0.1N hydrochloric acid or 10% ethanol is less than 0.05mg/ml; the solubility in absolute ethanol is 70mg/ml, and it is slightly soluble in propylene glycol.

use:

This product is an alkylating agent anti-cancer drug that can undergo an alkylation reaction with nucleophilic groups in cell components. Nucleic acid is the main target of alkylation, causing damage to the structure and function of DNA, cessation of cell division and reproduction, or death. It has good curative effect on brain glioma, lung cancer, lymphoma, etc., and also has certain curative effect on central nervous system leukemia. The oral LD50 for male mice is 51 mg/kg.

With anti-tumor drugs that affect the DNA of cells. Lomustine induces p53 expression in A2870 cells

production method:

2-Aminoethanol and urea are cyclized into 2-oxazolidinone, which is then reacted with cyclohexylamine to form N-(2-hydroxyethyl)-N'-cycloethylurea, which is then chlorinated with thionyl chloride. N-(2-chloroethyl)-N'-cyclohexyl urea is obtained, and finally cyclohexylnitrosourea is obtained through nitrosation reaction.

Package and transportation :

Package: 5g,25g,200g,500g,1kg